Nurse Practitioner Jobs in South Carolina, United States

1,000 jobs available

Find Nurse Practitioner opportunities in South Carolina, United States. Browse 1,000 open positions from top employers in the area.

Showing 20 of 1,000 jobs

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Nurse Practitioner, Evenings, Nights and Weekends Per Diem

Chapters Health System

Remote - South Carolina Part-time Remote

Chapters Health System’s ReNW Nurse Practitioner delivers fully remote virtual serious illness care management across hospice, palliative, and acute inpatient lines. The NP conducts virtual assessments, prescribes medication, and collaborates with interdisciplinary teams to ensure optimal patient and family support.

Last seen Jul 12, 2026
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Nurse Practitioner - Cardiology

Prisma Health

Maryville, South Carolina, United States of America Full-time On-site

Inspire health. Serve with compassion. Be the difference. Provides primary health care to a specific patient population within the guidelines of written protocols.

Last seen Jul 12, 2026
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Nurse Practitioner - NP/PA - Primary Care

CVS Health

South Carolina, South Carolina, United States Full-time On-site USD38 - USD81 / hour

At CVS Health, the Nurse Practitioner - NP/PA - Primary Care role at MinuteClinic in Irmo, SC offers a full‑time home clinic position with flexible scheduling and every other weekend coverage. The provider delivers holistic, evidence‑based primary and family care, managing assessment, diagnosis, treatment, and health counseling while coordinating with other health professionals.

Last seen Jul 11, 2026
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Nurse Practitioner, Evenings, Nights and Weekends Part-Time

Chapters Health System

Remote, South Carolina, United States Part-time Remote USD40 - USD60 / hour

Chapters Health System seeks a Part‑Time Nurse Practitioner to deliver fully remote virtual serious illness care management across its continuum of care, including home‑based, facility‑based, inpatient adult and pediatric hospice, palliative care, and PACE programs. The role requires at least 3 years of recent clinical experience in hospice, palliative, or acute inpatient settings, a Master’s or Doctorate in Nursing from an accredited Family or Adult NP program, and national certification, licensure, and prescriptive authority in the home state and any additional states where care is provided.

Last seen Jul 12, 2026
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Nurse Practitioner Resource Evening Nights & Weekends (Per Diem)

Chapters Health System

Remote, South Carolina, United States Part-time Remote USD52 - USD52 / hour

Chapters Health System is seeking a Part‑time Nurse Practitioner to provide fully remote virtual serious illness care management for patients and families across its continuum of care, including home‑based, facility‑based, inpatient adult and pediatric hospice, palliative care, and PACE programs. The role requires at least 3 years of recent clinical experience in hospice, palliative care, or acute inpatient settings, a Master’s or Doctoral degree in Nursing from an accredited Family or Adult NP program, and national certification and licensure in the home state and any additional states where care is delivered.

Last seen Jul 12, 2026
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Nurse Practitioner, Women's Care

McLeod Health

Manning, SC, United States Full-time On-site

McLeod Women's Care team provides comprehensive women's health services to the Clarendon community. The Nurse Practitioner assesses patients, develops and coordinates holistic care plans, performs examinations and preventive health measures, and collaborates with physicians and other health professionals.

Last seen Jul 12, 2026
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Nurse Practitioner

NHC and Affiliates

Sumter, South Carolina, United States Full-time On-site USD125 - USD125

Position: PRN Nurse Practitioner Pay: $125 Per Visit The Nurse Practitioner serves as a member of the Hospice Interdisciplinary Team and has responsibility for the medical component of the Hospice Patient Care Program. Collaborates with Medical Director and Attending Physician to provide skillful certifications and recertification assessments, including physical examinations, medical history & physical, diagnosis and treatment prescribing medications as needed, under the supervision of the Medical Director.

Last seen Jul 7, 2026
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Nurse Practitioner - Family Medicine Sumter, FT, Days

Prisma Health

Sumter, SC Full-time On-site

Provides primary health care to a specific patient population within the guidelines of written protocols. Follows established nursing standards, procedures, and practices.

Last seen Jul 12, 2026
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Nurse Practitioner - Psychiatry - Sumter

Prisma Health

Sumter, SC, United States of America Full-time On-site

Provides psychiatric care following protocols. Diagnoses conditions, screens for physical illness, offers individual/group counseling, writes prescriptions under supervision, monitors medication, manages cases, evaluates progress, educates staff/families, participates in operational assessments, research, and peer review.

Last seen Jul 12, 2026
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Nurse Practitioner - Cardiology

Prisma Health

Sumter, SC, United States of America Full-time On-site

Provides primary health care to cardiology patients, diagnosing and treating disease, prescribing treatments, charting, billing, participating in quality assurance, utilization management, education programs, managed care contracts, operational budgeting, revenue enhancement, and maintaining professional relationships.

Last seen Jul 12, 2026
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Nurse Practitioner - Hospice PRN

Crescent Hospice

Sumter,SC,USA Contract On-site

Crescent Hospice seeks dedicated Hospice Nurse Practitioners to deliver compassionate end‑of‑life care across Sumter, Florence, Marion and Richland counties. The role evaluates patients, creates personalized care plans, and collaborates with physicians, interdisciplinary teams, and families to ensure holistic support.

Last seen Jul 10, 2026
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Nurse Practitioner or Physician Assistant

Curana Health, Inc

Saint Matthews,SC,US Full-time On-site

Curana Health’s senior care team is dedicated to radically improving the health, happiness, and dignity of older adults through value‑based primary care in skilled nursing and senior living facilities. The Nurse Practitioner or Physician Assistant provides direct patient care, conducts comprehensive assessments, manages chronic conditions, and coordinates care with facility staff and families.

Last seen Jun 18, 2026
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Nurse Practitioner or Physician Assistant

Curana Health

Saint Matthews,SC,US Full-time On-site

Curana Health’s senior care team delivers proactive primary care to older adults in skilled nursing and senior living communities. The Nurse Practitioner or Physician Assistant provides comprehensive assessments, develops treatment plans, and conducts regular rounds to manage chronic conditions and promote wellness.

Last seen Jun 18, 2026
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Nurse Practitioner or Physician Assistant, SNF/LTC, Sat and Sun

Curana Health, Inc

Columbia,SC,USA Full-time On-site

Curana Health Clinical Team provides primary care to seniors in skilled nursing and assisted living facilities, aiming to improve health outcomes and quality of life. The Nurse Practitioner or Physician Assistant delivers comprehensive patient assessments, develops treatment plans, conducts regular rounds, and coordinates care with staff and families.

Last seen Jun 23, 2026
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Nurse Practitioner - Psychiatric (1 weekday/week)

Curana Health

Columbia,SC,USA Part-time On-site

Curana Health Psychiatric Care Team reimagines senior psychiatric services across skilled nursing, long‑term, assisted and independent living communities. The Psychiatric Nurse Practitioner provides comprehensive mental health evaluations, medication management, and patient/family education while collaborating with physicians and multidisciplinary staff.

Last seen Jul 12, 2026
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Nurse Practitioner or Physician Assistant - PRN

Curana Health, Inc

Columbia,SC,USA Part-time On-site

Curana Health Clinical Team drives senior health transformation by delivering primary care in skilled nursing and senior living communities. The Nurse Practitioner/Physician Assistant provides comprehensive patient assessments, develops treatment plans, conducts regular rounds, coordinates care with staff and families, educates residents, and documents care in the EMR while participating in quality improvement initiatives.

Last seen Jun 24, 2026
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Nurse Practitioner- PRN

ATC Columbia

Columbia,SC,USA Part-time On-site USD90 - USD90 / hour

ATC Columbia provides on-demand nursing staff to healthcare facilities. This Nurse Practitioner role delivers primary care, patient education, and collaborates with physicians to diagnose and treat acute and chronic conditions.

Last seen Jul 12, 2026
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Nurse Practitioner

ATC Columbia

Columbia,SC,USA Part-time On-site USD90 - USD90 / hour

ATC Columbia provides on-demand nursing staff to healthcare facilities nationwide. The Nurse Practitioner delivers primary care, diagnoses, and treatment plans while collaborating with physicians to ensure patient health and education.

Last seen Jul 12, 2026
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Nurse Practitioner - Palliative Care

Curana Health, Inc

Columbia,SC,USA Full-time On-site

Curana Health Palliative Care Team provides specialized, compassionate care to seniors in long‑term, assisted living and independent living settings, focusing on serious‑illness conversations, advance care planning, and symptom management. The Nurse Practitioner conducts comprehensive assessments, leads end‑of‑life discussions, prescribes treatments, and educates residents, families and facility staff on palliative best practices.

Last seen Jun 16, 2026
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Nurse Practitioner - Psychiatric (2-3 weekdays/week)

Curana Health, Inc

Columbia,SC,USA Part-time On-site

Curana Health Psychiatric Care team reimagines senior psychiatric services across skilled nursing, long‑term, assisted and independent living communities. The Psychiatric Nurse Practitioner conducts patient rounds, evaluates and manages mental health needs, coordinates care with physicians and staff, and prescribes treatments while educating residents and families.

Last seen Jun 18, 2026
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Nurse Practitioner Jobs in South Carolina: FAQ

How many Nurse Practitioner jobs in South Carolina are open right now?

1,000 Nurse Practitioner jobs in South Carolina are live on NextGig, all seen active within the last 45 days. The list refreshes daily as new roles are posted and filled ones drop off.

Which companies are hiring for Nurse Practitioner jobs in South Carolina?

Employers with current openings include Chapters Health System, Prisma Health, CVS Health, McLeod Health, NHC and Affiliates, Crescent Hospice, and others. Every listing links straight to the employer's application page.

What do Nurse Practitioner jobs in South Carolina pay?

6 of the 20 newest listings disclose pay, for example USD38 - USD81 / hour at CVS Health, USD40 - USD60 / hour at Chapters Health System, USD52 - USD52 / hour at Chapters Health System. Open a listing for the full compensation details.

Are any of these roles remote?

Of the 20 newest listings on this page, 3 are remote. The work model is shown on each job card.