Nurse Practitioner Jobs in South Carolina, United States

10,000 jobs available

Find Nurse Practitioner opportunities in South Carolina, United States. Browse 10,000 open positions from top employers in the area.

Showing 18 of 10,000 jobs

Nurse Practitioner- Laurens Family Medicine and Skilled Nursing Facilities - Laurens

Prisma Health

Laurens, South Carolina, United States Full-time On-site

Provide quality patient care under physician supervision, diagnosing and treating illnesses, managing charting and billing, participating in quality assurance, utilization management, and managed care contracts. Support operational budgeting and revenue enhancement.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

International SOS

Spartanburg, South Carolina, United States Full-time On-site

International SOS Nurse Practitioner role in Spartanburg, SC leading a high‑performing clinic delivering occupational health and emergency care. Leads patient assessment, diagnosis, treatment and medication prescribing while managing staff, pharmacy security and quality audits.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

Lexington Medical Center

West Columbia, South Carolina, United States Full-time On-site

Lexington Health's Nurse Practitioner role within the patient care team provides comprehensive assessment and management across the health‑illness continuum. The NP conducts interviews, physical exams, orders diagnostics, develops treatment plans, and educates patients on disease prevention and healthy lifestyles.

Last seen Oct 11, 2026
View details Apply

Neonatal Nurse Practitioner

Pediatrix

Columbia, South Carolina, United States Full-time On-site

Neonatal Nurse Practitioner team at Pediatrix provides comprehensive newborn and neonatology services across Prisma Health Richland and Prisma Health Baptist in Columbia, SC. The role delivers in‑house NICU coverage, performs procedures, attends deliveries, admits and rounds patients, teaches residents, and participates in CQI projects. Columbia, SC – on-site, full-time, with relocation assistance available.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner (Institutional)

Saratoga Medical Center

Charleston, South Carolina, United States Full-time On-site

Saratoga Medical Center is seeking a Nurse Practitioner (Institutional) to deliver advanced nursing care in inpatient settings across South Carolina. The NP will assess, diagnose, and manage acute, chronic, and psychiatric conditions in high‑risk environments such as mental health, correctional, and rehabilitation facilities, collaborating with multidisciplinary teams.

Last seen Oct 11, 2026
View details Apply

PRN‑Nurse Practitioner

DOCS Health

Rock Hill, South Carolina, United States Contract

DOCS Health’s PRN‑Nurse Practitioner team partners with U.S. military reserve units to deliver health readiness services. The role conducts physical health assessments, reviews medical histories, interviews service members, and documents findings for readiness classification.

Last seen Oct 11, 2026
View details Apply

Neonatal Nurse Practitioner

Pediatrix

Spartanburg, South Carolina, United States Full-time On-site

Neonatal Intensive Care Unit (NICU) at Spartanburg Regional Medical Center oversees a 35-bed Level-III NICU, delivering comprehensive neonatal care including high-frequency ventilation and hypothermia therapy. The Neonatal Nurse Practitioner provides 24‑hour in‑house shift coverage, collaborates with cardiology, surgery, ophthalmology, and a Maternal‑Fetal Medicine team, and supports a daily census of 25‑29 babies.

Last seen Oct 11, 2026
View details Apply

Neonatal Nurse Practitioner

US HealthCare Careers

Fort Mill, South Carolina, United States Full-time On-site

Neonatal Care Team at US HealthCare Careers provides specialized neonatal coverage across multiple NICUs in South Carolina. The Neonatal Nurse Practitioner delivers bedside care for high‑risk infants, collaborates with neonatologists on deliveries and rounds, and manages 12‑ and 24‑hour shift schedules.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner Full Time

Restore Hyper Wellness

Bluffton, SC Full-time

Restore Hyper Wellness is seeking a full-time Nurse Practitioner to join their wellness team in Hilton Head Island/Bluffton, SC. The role involves providing evidence-based care, managing the weight management program, administering IV Drip Therapy and Hyperbaric Oxygen Therapy, and supporting clients on their health and wellness journey in a fun, comfortable environment. The NP will work autonomously while collaborating with a multi-professional team to promote Restore's mission.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner Full Time

Restore Hyper Wellness

Charleston, South Carolina, United States Full-time On-site

Restore Hyper Wellness Clinical Team provides innovative wellness services to help clients feel better and achieve more. The Nurse Practitioner delivers evidence‑based care, manages weight‑loss programs, administers IV drips, hyperbaric oxygen and other therapies, and oversees medical inventory and EMR documentation.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

Lexington Medical Center

West Columbia, South Carolina, United States Full-time

Lexington Health in West Columbia, South Carolina, seeks a Nurse Practitioner for its Acute Care service line within Lexington Surgery. The role assesses patients' physical and psychosocial status, develops and implements treatment plans, and delivers diagnosis, treatment, and health education across the health-illness continuum within approved protocols.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

Lexington Medical Center

West Columbia, South Carolina, United States Full-time On-site

Lexington Health Acute Care team provides comprehensive inpatient and outpatient services at Lexington Medical Center, a 607‑bed teaching hospital in West Columbia, SC. The Nurse Practitioner assesses patients, develops treatment plans, and supervises clinical staff while ensuring quality and safety across the care continuum. West Columbia, SC, on-site, full-time role with competitive benefits and tuition reimbursement.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

Lexington Medical Center

West Columbia, South Carolina, United States Full-time On-site

Lexington Health's Nurse Practitioner team provides comprehensive patient assessment and chronic disease management across the West Columbia campus. The role conducts physical exams, orders diagnostics, develops treatment plans, and educates patients on health maintenance.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

Restore Hyper Wellness

Mount Pleasant, South Carolina, United States Full-time On-site

Restore Hyper Wellness team of wellness professionals delivers innovative, fun health services to help people feel better and do more. The Nurse Practitioner provides autonomous, evidence‑based care, manages weight‑loss programs, administers IV drips, hyperbaric oxygen and other therapies, and supports clinical operations.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner- Neurosurgery PRN

Prisma Health

Columbia, South Carolina, United States Part-time On-site

Nurse Practitioner in Neurosurgery delivers primary care, diagnoses and treats patients, documents care, participates in quality and educational initiatives, and supports operational budgeting.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

Lexington Medical Center

Columbia, South Carolina, United States Full-time On-site

Carolina Pulmon&Critical Care team at Lexington Health provides comprehensive pulmonary and critical care services to patients across the health‑illness continuum. The Nurse Practitioner assesses physical and psychosocial status, develops treatment plans, and supervises clinical triage while ensuring accurate documentation and compliance with protocols.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner

Lexington Medical Center

West Columbia, South Carolina, United States Part-time On-site

Lexington Health's Gastroenterology department seeks a Nurse Practitioner to provide comprehensive patient care, including assessments, diagnoses, and treatment planning. The role involves conducting physical exams, ordering diagnostics, managing chronic conditions, and educating patients on health maintenance.

Last seen Oct 11, 2026
View details Apply

Nurse Practitioner Palliative Care

NHC and Affiliates

Greenville, South Carolina, United States Full-time $100,000 - $110,000 / year

The Nurse Practitioner - Palliative Care at NHC and Affiliates, operating through the Greenville Caris location, manages health problems and coordinates health care for palliative care patients in accordance with State and Federal rules and regulations and the nursing standards of care. Day-to-day responsibilities include performing age-appropriate history and physicals for complex acute, critical, and chronically ill patients, ordering and interpreting diagnostic and therapeutic tests, prescrib

Last seen Oct 8, 2026
View details Apply

Nurse Practitioner Jobs in South Carolina: FAQ

How many Nurse Practitioner jobs in South Carolina are open right now?

10,000 Nurse Practitioner jobs in South Carolina are live on NextGig, all seen active within the last 45 days. The list refreshes daily as new roles are posted and filled ones drop off.

Which companies are hiring for Nurse Practitioner jobs in South Carolina?

Employers with current openings include Prisma Health, International SOS, Lexington Medical Center, Pediatrix, Saratoga Medical Center, DOCS Health, and others. Every listing links straight to the employer's application page.