Nurse Jobs in South Carolina, United States

10,000 jobs available

Find Nurse opportunities in South Carolina, United States. Browse 10,000 open positions from top employers in the area.

Showing 20 of 10,000 jobs

Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Columbia, South Carolina, United States Full-time On-site $29 - $29 / hour

Angels of Care Pediatric Home Health seeks RNs and LPNs to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Columbia, SC. The role involves administering treatments, assessing patient conditions, and educating families while collaborating with care teams. This position offers flexible scheduling options including full-time, part-time, and PRN shifts.

Last seen Oct 5, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Irmo, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to deliver one-on-one, in-home skilled nursing care for medically fragile children and young adults in Irmo, South Carolina and surrounding areas. Day-to-day work includes performing patient assessments, administering medications and therapies, coordinating care with families and providers, educating patients and families, and responding to changes in patient condition.

Last seen Oct 2, 2026
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Registered Nurse, Nurse Resident, Medical Nursing

Prisma Health

Columbia, SC Full-time On-site

Medical Nursing team at Prisma Health delivers comprehensive patient care and supports new graduate nurses through a structured residency program. The Resident Nurse attends core curriculum classes, participates in professional development workshops, and completes clinical competencies under supervision, gaining hands‑on experience in a 10E Medical Nursing unit.

Last seen Oct 11, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Fort Mill, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to deliver one-on-one, in-home skilled nursing care for medically fragile children and young adults in Fort Mill, South Carolina and surrounding areas. Day-to-day responsibilities include performing patient assessments, administering medications and therapies, coordinating care with families and providers, and educating patients and families to support improved outcomes.

Last seen Sep 29, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Lancaster, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Lancaster, South Carolina and surrounding areas. Day-to-day, nurses perform patient assessments, administer medications and therapies, coordinate care with families and providers, educate patients and families, and respond to changes in patient condition.

Last seen Oct 5, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Simpsonville, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Registered Nurses (RNs) and Licensed Practical Nurses (LPNs) in Simpsonville, SC and surrounding areas to provide one-on-one, in-home care for medically fragile children and young adults. Nurses deliver skilled nursing care, perform ongoing assessments, administer medications and therapies, coordinate care with families and providers, and educate patients and families to support improved outcomes.

Last seen Oct 5, 2026
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Registered Nurse, Nurse Resident, Intermediate ICU

Prisma Health

Sumter, South Carolina, United States Full-time On-site

Critical Care Services at Prisma Health trains new graduate nurses through a Nurse Residency Program that blends core clinical training with specialty-specific education in the Intermediate ICU. The Registered Nurse Resident provides direct patient care under supervision, completes assessments, develops care plans, and participates in quality improvement while learning essential nursing skills. Sumter, SC, on-site, hybrid schedule with variable shifts.

Last seen Oct 11, 2026
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Registered Nurse (PRN) - 4th Nursing/Routine - Loris

McLeod Health

Loris, South Carolina, United States Part-time On-site

McLeod Health Nursing team provides compassionate patient care across its Loris facility. The Registered Nurse delivers age‑specific nursing interventions, mentors novice staff, and floats to assist other units as needed.

Last seen Oct 11, 2026
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Staff Nurse PRN, Nursing Administration Seacoast

McLeod Health

Little River, South Carolina, United States Part-time On-site

Nursing Administration Seacoast at McLeod Health provides comprehensive inpatient care across the Seacoast region. The Staff Nurse (PRN) delivers patient assessments, age‑specific interventions, and collaborates on evidence‑based practices while floating to support other units as needed.

Last seen Oct 11, 2026
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Registered Nurse (RN)- Nurse Resident, December 2026, Emergency Department

Prisma Health

Columbia, SC Full-time

The Registered Nurse (RN) Nurse Resident role in the Emergency Department at Baptist Parkridge Hospital (Prisma Health) in Columbia, SC is a full-time position for new graduate nurses. The role involves attending quality and core curriculum classes, participating in professional development workshops and peer support groups, and completing clinical competencies and validation requirements under the supervision of the Clinical Education Team and a licensed RN. Day-to-day duties include patient as

Last seen Sep 28, 2026
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Registered Nurse - Interventional Specialist, Radiology Nursing Services

Prisma Health

Columbia, South Carolina, United States Full-time On-site

Radiology Nursing Services team at Prisma Health provides clinical direction for diagnostic and interventional radiology procedures. The RN delivers patient pre‑procedure assessment, moderate sedation, circulates with the procedural team, and documents care throughout the case.

Last seen Oct 11, 2026
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Clinician (Advanced Practice Nurse or Certified Nurse Midwife)

Ppsat

Charleston, SC Full-time On-site $58 - $72 / hour

Planned Parenthood South Atlantic (PPSAT) seeks a Clinician (Advanced Practice Nurse or Certified Nurse Midwife) to deliver inclusive, non-judgmental reproductive and primary care across its Columbia and Charleston, SC health centers. Day-to-day, you will conduct reproductive health exams, diagnose and treat STIs, provide family planning and clinical abortion care, prescribe contraceptives, counsel patients of all genders, and support quality, coding, and training activities.

Last seen Oct 11, 2026
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Clinician, Advanced Practice Nurse, Certified Nurse Midwife

Ppsat

South Carolina, United States Part-time Hybrid $58 - $72 / hour

Patient Services team at Planned Parenthood South Atlantic provides inclusive reproductive healthcare across South Carolina. The Clinician, Advanced Practice Nurse or Certified Nurse Midwife remotely interprets first and second trimester ultrasounds each Wednesday, collaborates with multidisciplinary teams, and may take optional PRN clinical shifts at Charleston or Columbia health centers.

Last seen Sep 29, 2026
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Registered Nurse (RN) - Nurse Resident, December 2026, Nephrology

Prisma Health

Sumter, South Carolina, United States Full-time On-site

Nephrology Nurse Residency Program at Prisma Health. New graduate nurses rotate through core curriculum classes, professional development workshops, and hands‑on clinical mentorship to build foundational nursing skills.

Last seen Oct 11, 2026
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Registered Nurse, Nurse Resident, Cardiac Telemetry

Prisma Health

Columbia, South Carolina, United States Full-time On-site

Nurse Residency Program at Prisma Health builds a strong foundation for new graduate nurses through core clinical training and specialty education. The Resident RN provides direct patient care on the Cardiac Telemetry unit, collects data, develops care plans, and documents under RN supervision.

Last seen Oct 11, 2026
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Registered Nurse (RN) - Nurse Resident, December 2026, Spine Unit

Prisma Health

Columbia, South Carolina, United States Full-time On-site

Nurse Residency Program at Prisma Health, Adult Multispecialty Services, Spine Unit. The role supports new graduate nurses through core curriculum classes, professional development workshops, and clinical competency validation under supervision of the Clinical Education Team.

Last seen Oct 11, 2026
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Registered Nurse (RN) – Skilled Nursing & Clinical Care (Home Care)

BrightStar Care

Bluffton, Savannah, SC Full-time

BrightStar Care is seeking a Registered Nurse (RN) for its Bluffton, South Carolina home care team to deliver skilled nursing and clinical oversight to clients in their homes. The RN will work primarily from the Bluffton office during Monday–Friday business hours, performing comprehensive nursing assessments, developing care plans, and coordinating skilled services, with occasional travel to patients’ homes for hands-on care and assessments.

Last seen Oct 11, 2026
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Registered Nurse (RN) Charge Nurse - Clinical Unit Leader - Medical PCU - St. Francis Downtown

Bon Secours Health System

Greenville, SC Full-time On-site

Bon Secours seeks a Registered Nurse Charge Nurse to lead the Medical PCU at St. Francis Downtown in Greenville, SC. This role coordinates patient care, manages staff, and ensures clinical excellence within a faith-based organization. The position is full-time with evening or night shifts.

Last seen Oct 11, 2026
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Registered Nurse (RN) – Nurse Resident, December 2026, Cardiac Telemetry

Prisma Health

Seneca, South Carolina, United States Full-time On-site

Cardiac Telemetry team at Prisma Health provides specialized cardiac monitoring and patient care. The Nurse Resident will support patient assessments, develop care plans, and document care under RN supervision while completing the residency curriculum.

Last seen Oct 11, 2026
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Registered Nurse (RN) - Clinical Nurse Educator I, Pediatrics, Full-Time, Days

Prisma Health

Columbia, SC Full-time

The Clinical Nurse Educator I in Pediatrics at Prisma Health prepares the healthcare workforce for the clinical setting by teaching competency-based curriculum programs. Day-to-day duties include delivering classroom and simulation training for newly hired or transferring clinical team members, providing annual and as-needed competency-based training to maintain regulatory requirements, and offering role-based educational instruction across the Prisma Health system.

Last seen Oct 11, 2026
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Nurse Jobs in South Carolina: FAQ

How many Nurse jobs in South Carolina are open right now?

10,000 Nurse jobs in South Carolina are live on NextGig, all seen active within the last 45 days. The list refreshes daily as new roles are posted and filled ones drop off.

Which companies are hiring for Nurse jobs in South Carolina?

Employers with current openings include Angels of Care, Prisma Health, McLeod Health, Ppsat, BrightStar Care, Bon Secours Health System. Every listing links straight to the employer's application page.

What do Nurse jobs in South Carolina pay?

7 of the 20 newest listings disclose pay, for example $29 - $29 / hour at Angels of Care, $29 - $29 / hour at Angels of Care, $29 - $29 / hour at Angels of Care. Open a listing for the full compensation details.

Are any of these roles remote?

Of the 20 newest listings on this page, 1 is hybrid. The work model is shown on each job card.