Physician Assistant Jobs in South Carolina, United States

10,000 jobs available

Find Physician Assistant opportunities in South Carolina, United States. Browse 10,000 open positions from top employers in the area.

Showing 18 of 10,000 jobs

Nurse Practitioner or Physician Assistant - First Assist Outpatient - Neurosurgery

Medical University of South Carolina (MUSC)

Charleston,SC,United States of America Full-time

Neurosurgery First Assist team at Medical University of South Carolina (MUSC) delivers peri‑operative and outpatient spine care. The role supports neurosurgeons in the OR, manages outpatient clinic flow, and coordinates patient care across inpatient and outpatient settings.

Last seen Aug 26, 2026
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Physician Assistant I

Saratoga Medical Center

Greenville,SC,US Full-time On-site $47 - $88 / hour

Saratoga Medical Center is hiring a Physician Assistant I to deliver high-quality patient care across its South Carolina facilities. The PA conducts assessments, diagnoses, treats illnesses, prescribes medications, and collaborates with physicians and staff to ensure optimal outcomes.

Last seen Aug 26, 2026
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Physician Assistant

Lexington Medical Center

West Columbia, SC, US Full-time

Lexington Health's LH Heart&Vasc Vascular Surgery department seeks a Physician Assistant to deliver direct health care services to patients of all ages under physician supervision. The role assesses physical and psychosocial status, develops and implements treatment plans, and provides diagnosis and treatment for acute illnesses, chronic disease maintenance, and interim physical exams within prescribed guidelines.

Last seen Aug 26, 2026
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Physician Assistant

Lexington Medical Center

Columbia, SC, US Full-time

Lexington Health (Lex ENT Northeast) seeks a Physician Assistant to deliver direct health care services to patients of all ages under physician supervision. Day-to-day duties include assessing physical and psychosocial status, developing and implementing treatment plans, diagnosing and treating common acute illnesses, managing stable chronic conditions, performing interim physical exams, counseling on health maintenance, and maintaining accurate documentation.

Last seen Aug 26, 2026
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Physician Assistant

Comprehensive Rehab Consultants

Rock Hill, SC, US Full-time Remote

Comprehensive Rehab Consultants (CRC) is revolutionizing skilled nursing facility care by enhancing patient functional ability and quality of life. As a PM&R Clinician, you will provide specialized rehabilitation services at designated facilities in Rock Hill or Lancaster, SC, collaborating with interdisciplinary teams to optimize patient outcomes.

Last seen Aug 26, 2026
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Psychiatric Physician Assistant

Purple Cow Recruiting

Hartsville,SC,USA Full-time Hybrid

Outpatient Behavioral Health Practice provides psychiatric assessments, diagnosis, and medication management. The Psychiatric Physician Assistant conducts comprehensive evaluations, develops treatment plans, and manages medications while collaborating with primary care and behavioral health teams.

Last seen Aug 19, 2026
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Per Diem Physician Assistant

Arthritis Knee Pain Centers

Columbia,SC,USA Full-time On-site

Arthritis Knee Pain Centers' Orthopedic Medicine team provides non-surgical, non-opioid care for knee osteoarthritis. The Physician Assistant evaluates patients, conducts diagnostic tests, develops treatment plans, and educates patients on therapies.

Last seen Aug 26, 2026
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Physician Assistant II

Saratoga Medical Center

Greenville,SC,US Full-time On-site $39 - $72 / hour

Saratoga Medical Center seeks a Physician Assistant II to deliver advanced healthcare services across its South Carolina facilities. The PA provides patient care under physician supervision, develops treatment plans, and collaborates with the clinical team to establish protocols and monitor outcomes.

Last seen Aug 26, 2026
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Physician Assistant

Lexington Medical Center

West Columbia,SC,USA Full-time On-site

Lexington Health Oncology team provides comprehensive cancer care within a 607‑bed teaching hospital. The Physician Assistant assesses patients, develops treatment plans, performs examinations, and prescribes under physician supervision.

Last seen Aug 26, 2026
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Physician Assistant

Lexington Medical Center

West Columbia,South Carolina,USA Full-time On-site

Lexington Health, a comprehensive network of care in West Columbia, South Carolina, delivers a wide range of medical services including a 607‑bed teaching hospital. The Physician Assistant assesses patients, develops treatment plans, and provides direct care across all ages under physician supervision.

Last seen Aug 26, 2026
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Physician Assistant - Orthopedics - Florence

McLeod Health

Florence, SC, United States Full-time On-site

McLeod Orthopaedics Florence provides comprehensive orthopedic care to patients across the region. The Physician Assistant delivers patient assessments, performs examinations, and collaborates with physicians to develop holistic treatment plans.

Last seen Aug 26, 2026
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Physician Assistant - Vascular Associates

McLeod Health

SC, United States Full-time On-site

Vascular Associates team at McLeod Health provides specialized vascular care across South Carolina. The Physician Assistant delivers patient assessments, performs physical examinations, and coordinates care plans with physicians to ensure comprehensive treatment.

Last seen Aug 26, 2026
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Nurse Practitioner or Physician Assistant

Curana Health

Georgetown,SC,USA Full-time On-site

Clinical Care Team at Curana Health delivers proactive primary care to seniors in skilled nursing and independent living communities. The Nurse Practitioner or Physician Assistant provides comprehensive assessments, chronic disease management, and care coordination across facilities, documenting in EMR and participating in quality improvement initiatives.

Last seen Aug 26, 2026
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Physician Assistant - McLeod Cardiology Associates Florence

McLeod Health

Florence,SC,United States Full-time

McLeod Cardiology Associates Florence, part of McLeod Health, delivers comprehensive cardiovascular care to the South Carolina community. The Physician Assistant supports physicians in patient assessment, physical exams, and care planning, ensuring high standards of professionalism and compassion.

Last seen Aug 26, 2026
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Emergency Medicine Physician Assistant

Tidelands Health

Murrells Inlet, SC, United States Full-time

Tidelands Health Emergency Medicine team provides acute care across two coastal hospitals, delivering comprehensive emergency services to the Myrtle Beach region. The Physician Assistant will deliver board‑certified emergency care, manage 12‑hour day shifts, and utilize Epic EMR to coordinate patient treatment.

Last seen Aug 20, 2026
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Physician Assistant - Lexington Urology

Lexington Medical Center

West Columbia, SC, USA Full-time On-site

Lexington Health's Urology team provides comprehensive patient care across the health‑illness continuum. The Physician Assistant delivers direct clinical services, performs examinations, orders diagnostics, and develops treatment plans under physician supervision.

Last seen Aug 20, 2026
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Nurse Practitioner or Physician Assistant

Four Winds Health

Easley,SC,United States Full-time|part-time On-site

Prisma Health Urgent Care team delivers high‑quality urgent care to adults and children in Easley, SC. The Nurse Practitioner or Physician Assistant provides comprehensive patient assessments, performs procedures, and coordinates care with physicians while maintaining accurate documentation. This on‑site role offers a flexible 3‑day/12‑hour week schedule with both full‑time (30‑36 hrs) and part‑time (24 hrs) options.

Last seen Aug 26, 2026
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Nurse Practitioner or Physician Assistant

Curana Health

Florence, SC, US Full-time On-site

Curana Health is on a mission to radically improve the health, happiness, and dignity of older adults through value‑based care. The Nurse Practitioner or Physician Assistant provides direct primary care in skilled nursing and senior living facilities, performing assessments, developing treatment plans, coordinating with staff and families, and driving quality improvement initiatives.

Last seen Aug 26, 2026
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Physician Assistant Jobs in South Carolina: FAQ

How many Physician Assistant jobs in South Carolina are open right now?

10,000 Physician Assistant jobs in South Carolina are live on NextGig, all seen active within the last 45 days. The list refreshes daily as new roles are posted and filled ones drop off.

Which companies are hiring for Physician Assistant jobs in South Carolina?

Employers with current openings include Medical University of South Carolina (MUSC), Saratoga Medical Center, Lexington Medical Center, Comprehensive Rehab Consultants, Purple Cow Recruiting, Arthritis Knee Pain Centers, and others. Every listing links straight to the employer's application page.

What do Physician Assistant jobs in South Carolina pay?

2 of the 18 newest listings disclose pay, for example $47 - $88 / hour at Saratoga Medical Center, $39 - $72 / hour at Saratoga Medical Center. Open a listing for the full compensation details.

Are any of these roles remote?

Of the 18 newest listings on this page, 1 is remote and 1 is hybrid. The work model is shown on each job card.