Physician Assistant Jobs in South Carolina, United States

10,000 jobs available

Find Physician Assistant opportunities in South Carolina, United States. Browse 10,000 open positions from top employers in the area.

Showing 17 of 10,000 jobs

Nurse Practitioner or Physician Assistant - First Assist Outpatient - Neurosurgery

Medical University of South Carolina (MUSC)

Charleston, South Carolina, United States Full-time

Neurosurgery First Assist team at Medical University of South Carolina (MUSC) delivers peri‑operative and outpatient spine care. The role supports neurosurgeons in the OR, manages outpatient clinic flow, and coordinates patient care across inpatient and outpatient settings.

Last seen Sep 27, 2026
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Physician Assistant I

Saratoga Medical Center

Greenville, South Carolina, United States Full-time On-site $47 - $88 / hour

Saratoga Medical Center is hiring a Physician Assistant I to deliver high-quality patient care across its South Carolina facilities. The PA conducts assessments, diagnoses, treats illnesses, prescribes medications, and collaborates with physicians and staff to ensure optimal outcomes.

Last seen Oct 11, 2026
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Physician Assistant

Lexington Medical Center

West Columbia, South Carolina, United States Full-time

Lexington Health's LH Heart&Vasc Vascular Surgery department seeks a Physician Assistant to deliver direct health care services to patients of all ages under physician supervision. The role assesses physical and psychosocial status, develops and implements treatment plans, and provides diagnosis and treatment for acute illnesses, chronic disease maintenance, and interim physical exams within prescribed guidelines.

Last seen Oct 11, 2026
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Physician Assistant II

Saratoga Medical Center

Greenville, South Carolina, United States Full-time On-site $39 - $72 / hour

Saratoga Medical Center seeks a Physician Assistant II to deliver advanced healthcare services across its South Carolina facilities. The PA provides patient care under physician supervision, develops treatment plans, and collaborates with the clinical team to establish protocols and monitor outcomes.

Last seen Oct 11, 2026
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Per Diem Physician Assistant

Arthritis Knee Pain Centers

Columbia, South Carolina, United States Full-time On-site

Arthritis Knee Pain Centers' Orthopedic Medicine team provides non-surgical, non-opioid care for knee osteoarthritis. The Physician Assistant evaluates patients, conducts diagnostic tests, develops treatment plans, and educates patients on therapies.

Last seen Oct 11, 2026
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Physician Assistant - Orthopedics - Florence

McLeod Health

South Carolina, United States Full-time On-site

McLeod Orthopaedics Florence provides comprehensive orthopedic care to patients across the region. The Physician Assistant delivers patient assessments, performs examinations, and collaborates with physicians to develop holistic treatment plans.

Last seen Oct 11, 2026
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Physician Assistant - Vascular Associates

McLeod Health

South Carolina, United States Full-time On-site

Vascular Associates team at McLeod Health provides specialized vascular care across South Carolina. The Physician Assistant delivers patient assessments, performs physical examinations, and coordinates care plans with physicians to ensure comprehensive treatment.

Last seen Oct 11, 2026
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Nurse Practitioner or Physician Assistant

Curana Health, Inc

Cheraw, South Carolina, United States Full-time

Curana Health seeks a Nurse Practitioner or Physician Assistant to deliver high-quality primary care in skilled nursing and senior living facilities across multiple states. You will provide direct patient care, manage chronic conditions, coordinate with facility staff and families, and support quality improvement initiatives.

Last seen Oct 11, 2026
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Nurse Practitioner or Physician Assistant

Curana Health

Florence, South Carolina, United States Full-time On-site

Curana Health is on a mission to radically improve the health, happiness, and dignity of older adults through value‑based care. The Nurse Practitioner or Physician Assistant provides direct primary care in skilled nursing and senior living facilities, performing assessments, developing treatment plans, coordinating with staff and families, and driving quality improvement initiatives.

Last seen Oct 11, 2026
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Physician Assistant, Pain Management

Self Regional

Greenwood, South Carolina, United States Full-time On-site

Pain Management Team at Self Regional Healthcare provides comprehensive pain assessment and treatment for patients across the region. The Physician Assistant conducts medical histories, physical exams, and collaborates with physicians to develop and implement individualized pain management plans, performing procedures within scope of practice.

Last seen Oct 11, 2026
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Nurse Practitioner or Physician Assistant

Self Regional

Greenwood, South Carolina, United States Full-time On-site

Self Regional Healthcare clinic provides primary and specialty care to the Greenwood community. The Nurse Practitioner or Physician Assistant assesses patients in clinic and contracted facilities, completes histories, exams, and documents care in the EMR while supporting Meaningful Use measures.

Last seen Oct 11, 2026
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Physician Assistant - Cardiothoracic Surgical Associates

McLeod Health

South Carolina, United States Full-time On-site

McLeod Cardiothoracic Associates Florence is seeking a Physician Assistant to join their cardiothoracic surgical team in Florence, SC. The role involves assessing patient needs through history, observation, physical examination, and diagnostic data analysis, then recording findings and formulating care plans. The PA performs physical examinations and preventative health measures within physician guidelines, discusses cases with physicians and other health professionals, and coordinates holistic,

Last seen Oct 8, 2026
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Nurse Practitioner or Physician Assistant | Scuffletown

Four Winds Health

Simpsonville, South Carolina, United States Full-time On-site

Prisma Health Urgent Care seeks dedicated Nurse Practitioners and Physician Assistants to deliver high‑quality urgent care to adults and children. The role involves evaluating, treating, and coordinating patient care, documenting encounters, and supporting clinic operations.

Last seen Oct 11, 2026
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Physician Assistant / Nurse Practitioner - Trauma - Columbia

Prisma Health

Columbia, SC Full-time On-site

Prisma Health's Trauma Surgery team seeks a Physician Assistant to deliver high-quality patient care in Columbia, SC. The role involves performing exams, ordering diagnostics, diagnosing conditions, and providing emergency treatment under physician supervision. This full-time position is located at the Richland facility.

Last seen Oct 11, 2026
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Physician Assistant - Orthopedics - Rock Hill, SC

Tenet Healthcare

Rock Hill, South Carolina, United States Full-time On-site

Tenet Healthcare is seeking an experienced Physician Assistant to join the Piedmont Physician Network’s Orthopedics team in Rock Hill, South Carolina. The role supports orthopedic surgeons across the operating room, inpatient setting, and outpatient clinics, providing OR support, inpatient rounding, and outpatient clinic coverage.

Last seen Oct 11, 2026
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Physician Assistant - Pee Dee Surgical - Day Shift

McLeod Health

South Carolina, United States Full-time On-site

Physician Assistant role at Pee Dee Surgical, focusing on day shift patient care and collaboration with physicians.

Last seen Sep 30, 2026
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Night Shift Physician Assistant - Intensivists

McLeod Health

South Carolina, United States Full-time On-site

McLeod Regional Medical Center seeks a dedicated Night Shift Physician Assistant to join its intensive care team. The role involves comprehensive patient assessment, physical examinations, and care coordination within a 24/7 staffing model.

Last seen Oct 11, 2026
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Physician Assistant Jobs in South Carolina: FAQ

How many Physician Assistant jobs in South Carolina are open right now?

10,000 Physician Assistant jobs in South Carolina are live on NextGig, all seen active within the last 45 days. The list refreshes daily as new roles are posted and filled ones drop off.

Which companies are hiring for Physician Assistant jobs in South Carolina?

Employers with current openings include Medical University of South Carolina (MUSC), Saratoga Medical Center, Lexington Medical Center, Arthritis Knee Pain Centers, McLeod Health, Curana Health, Inc, and others. Every listing links straight to the employer's application page.

What do Physician Assistant jobs in South Carolina pay?

2 of the 17 newest listings disclose pay, for example $47 - $88 / hour at Saratoga Medical Center, $39 - $72 / hour at Saratoga Medical Center. Open a listing for the full compensation details.