Registered Nurse Jobs in South Carolina, United States

10,000 jobs available

Find Registered Nurse opportunities in South Carolina, United States. Browse 10,000 open positions from top employers in the area.

Showing 19 of 10,000 jobs

Licensed Practical Nurse / Registered Nurse – Private Duty Pediatric Nurse

Angels of Care

Simpsonville, South Carolina, USA Full-time On-site

Angels of Care Pediatric Home Health provides one‑on‑one in‑home care for medically fragile children and young adults, delivering high‑quality, individualized nursing in the patient’s home. The nurse provides skilled assessments, medication administration, and care coordination while educating families and ensuring safety.

Last seen Aug 24, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Greenville, South Carolina, United States Full-time On-site $29 - $29 / hour

Angels of Care Pediatric Home Health seeks RNs and LPNs to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Greenville, SC. The role involves patient assessments, medication administration, and family education within a flexible scheduling model. This position supports the organization's mission to deliver high-quality, compassionate home health services.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Gaffney, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Gaffney, South Carolina and surrounding areas. Nurses perform patient assessments, administer medications and therapies, coordinate care with families and providers, and educate patients and families while delivering individualized care in a home setting.

Last seen Aug 27, 2026
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Registered Nurse (RN) - Nurse Resident, September 2026, Inpatient Rehabilitation Nursing

Prisma Health

Greenville,SC,United States of America Full-time

Nurse Residency Program at Prisma Health’s Roger C. Peace Rehabilitation Hospital in Greenville, SC. The program trains new RN graduates through core curriculum classes, clinical competencies, and peer support groups under direct supervision of licensed RNs. Residents manage patient assessments, care plans, and documentation while participating in quality improvement and multidisciplinary coordination. Onsite work in a 3‑day per week schedule with full‑time commitment.

Last seen Aug 24, 2026
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Registered Nurse, Nurse Resident, Medical Nursing

Prisma Health

Richland,SC,United States of America Full-time On-site

Medical Nursing team at Prisma Health delivers comprehensive patient care and supports new graduate nurses through a structured residency program. The Resident Nurse attends core curriculum classes, participates in professional development workshops, and completes clinical competencies under supervision, gaining hands‑on experience in a 10E Medical Nursing unit.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Columbia, South Carolina, United States Full-time On-site $29 - $29 / hour

Angels of Care Pediatric Home Health seeks RNs and LPNs to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Columbia, SC. The role involves administering treatments, assessing patient conditions, and educating families while collaborating with care teams. This position offers flexible scheduling options including full-time, part-time, and PRN shifts.

Last seen Aug 27, 2026
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Registered Nurse (RN) - Nurse Resident, September/October 2026, Surgical Trauma Nursing

Prisma Health

Richland, SC, United States Full-time On-site
Last seen Aug 14, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Clinton, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Registered Nurses (RNs) and Licensed Practical Nurses (LPNs) to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Clinton, SC and surrounding areas. Nurses perform patient assessments, administer medications and treatments, coordinate care with families and providers, and educate patients and families to support improved outcomes.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Gaffney,South Carolina,USA Full-time On-site

Angels of Care Pediatric Home Health provides one‑on‑one, in‑home care for medically fragile children and young adults. The nurse delivers skilled nursing care, conducts patient assessments, administers medications and therapies, and coordinates with families and providers to ensure safe, high‑quality care.

Last seen Aug 24, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Spartanburg, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Spartanburg, SC and surrounding areas. Day-to-day duties include performing patient assessments, administering medications and therapies, coordinating care with families and providers, and educating patients and families to support improved outcomes.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Johnston, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to deliver one-on-one, in-home skilled nursing care for medically fragile children and young adults in Johnston, SC and surrounding areas. Day-to-day, you will perform patient assessments, administer medications and therapies, coordinate care with families and providers, educate caregivers, and respond to changes in patient condition.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Lexington, South Carolina, United States Full-time On-site $29 - $29 / hour

Angels of Care Pediatric Home Health seeks RNs and LPNs to provide one-on-one, in-home skilled nursing care for medically fragile children and young adults in Lexington, SC. The role involves administering treatments, assessing patient conditions, and educating families while collaborating with care teams. This position offers flexible scheduling options including full-time, part-time, and PRN shifts.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Charleston, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to deliver one-on-one, in-home skilled nursing care for medically fragile children and young adults in Charleston, SC and surrounding areas. Day-to-day, nurses perform patient assessments, administer medications and therapies, coordinate care with families and providers, educate patients and families, and respond to changes in patient condition.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Sumter, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to provide one-on-one, in-home care for medically fragile children and young adults in Sumter, SC and surrounding areas. Nurses perform skilled nursing care, ongoing assessments, medication and treatment administration, care coordination with families and providers, and patient/family education in a home setting.

Last seen Aug 27, 2026
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Registered Nurse - Nurse Resident, Emergency Department

Prisma Health

Greer, SC, United States Full-time On-site

Emergency Services at Prisma Health. The Nurse Resident program provides structured education, clinical skill development, and mentorship for new Registered Nurses in the Emergency Department, focusing on patient assessment, care planning, and interdisciplinary collaboration. Night shift, Greer, SC, on-site campus with full-time schedule.

Last seen Aug 27, 2026
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Registered Nurse (PRN) - 4th Nursing/Routine - Loris

McLeod Health

Loris, SC, United States Part-time On-site

McLeod Health Nursing team provides compassionate patient care across its Loris facility. The Registered Nurse delivers age‑specific nursing interventions, mentors novice staff, and floats to assist other units as needed.

Last seen Aug 27, 2026
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Registered Nurse, Nurse Resident, Intermediate ICU

Prisma Health

Sumter, SC, United States Full-time On-site

Critical Care Services at Prisma Health trains new graduate nurses through a Nurse Residency Program that blends core clinical training with specialty-specific education in the Intermediate ICU. The Registered Nurse Resident provides direct patient care under supervision, completes assessments, develops care plans, and participates in quality improvement while learning essential nursing skills. Sumter, SC, on-site, hybrid schedule with variable shifts.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Simpsonville, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Registered Nurses (RNs) and Licensed Practical Nurses (LPNs) in Simpsonville, SC and surrounding areas to provide one-on-one, in-home care for medically fragile children and young adults. Nurses deliver skilled nursing care, perform ongoing assessments, administer medications and therapies, coordinate care with families and providers, and educate patients and families to support improved outcomes.

Last seen Aug 27, 2026
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Licensed Practical Nurse (LPN) / Registered Nurse (RN) – Private Duty Pediatric Nurse

Angels of Care

Fort Mill, South Carolina, United States Full-time $29 - $29 / hour

Angels of Care Pediatric Home Health is hiring Licensed Practical Nurses (LPNs) and Registered Nurses (RNs) to deliver one-on-one, in-home skilled nursing care for medically fragile children and young adults in Fort Mill, South Carolina and surrounding areas. Day-to-day responsibilities include performing patient assessments, administering medications and therapies, coordinating care with families and providers, and educating patients and families to support improved outcomes.

Last seen Aug 27, 2026
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Registered Nurse Jobs in South Carolina: FAQ

How many Registered Nurse jobs in South Carolina are open right now?

10,000 Registered Nurse jobs in South Carolina are live on NextGig, all seen active within the last 45 days. The list refreshes daily as new roles are posted and filled ones drop off.

Which companies are hiring for Registered Nurse jobs in South Carolina?

Employers with current openings include Angels of Care, Prisma Health, McLeod Health. Every listing links straight to the employer's application page.

What do Registered Nurse jobs in South Carolina pay?

11 of the 19 newest listings disclose pay, for example $29 - $29 / hour at Angels of Care, $29 - $29 / hour at Angels of Care, $29 - $29 / hour at Angels of Care. Open a listing for the full compensation details.