Registered Nurse Jobs in South Dakota, United States

207 jobs available

Find Registered Nurse opportunities in South Dakota, United States. Browse 207 open positions from top employers in the area.

Showing 20 of 207 jobs

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Registered Nurse (RN) or Licensed Practical Nurse (LPN) | Pediatric Clinic

Avera Health

Pierre, SD, United States of America Full-time On-site USD24 - USD41 / hour

Avera Pierre Clinic’s Pediatric team seeks a dedicated RN or LPN to serve as primary nurse for Dr. Natalie Hutton, supporting a high‑volume practice. The role involves administering medications, coordinating patient care, and educating families while rotating with staff for acute care coverage on Fridays and Saturdays.

Last seen Jul 12, 2026
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Registered Nurse (RN) | ICU

Avera Health

Pierre,SD,United States of America Full-time USD32 - USD48 / hour

Avera St Mary's Hospital ICU team delivers critical nursing care to patients in a multidisciplinary setting. The RN manages patient care plans, coordinates with physicians and support staff, and ensures safe, infection‑controlled environments.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Oncology Infusion

Avera Health

Pierre, SD, United States Full-time On-site USD31 - USD46 / hour

Oncology Infusion team at Avera St. Mary's Hospital provides specialized nursing care for cancer patients receiving infusion therapies. The RN develops care plans, administers treatments, educates patients and families, and coordinates with physicians and staff.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Cancer Institute Navigation PRN

Avera Health

Pierre,SD,US Part-time Hybrid USD28 - USD41 / hour

Avera Cancer Institute Navigation team provides coordinated oncology support across six locations, guiding patients through care pathways and resources. The RN serves as the primary contact via phone and in‑person, conducting assessments, triaging, making referrals, and delivering education to improve patient experience.

Last seen Jul 12, 2026
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Registered Nurse (RN) or Licensed Practical Nurse (LPN) | OB Clinic and Float Nurse

Avera Health

Pierre,SD,USA Full-time On-site USD24 - USD41 / hour

OB Clinic and Float Nurse at Avera Health provides compassionate nursing care to OB patients and supports clinic operations. The role performs general nursing care, administers medications, prepares equipment, coordinates patient flow, and educates patients and families.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Internal Medicine Clinic

Avera Health

Pierre,SD,USA Full-time On-site USD28 - USD41 / hour

Internal Medicine Clinic at Avera Pierre Clinic provides comprehensive primary care. The RN delivers direct patient care, administers medications, coordinates clinic flow, and supports providers during procedures while ensuring accurate documentation and patient education.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Outpatient Treatment Center (OTC) | PRN

Avera Health

Pierre,SD,United States Part-time USD31 - USD48 / hour

Registered Nurse (RN) at Avera St Mary's Hospital in Pierre, SD. The RN provides comprehensive nursing care in the Outpatient Treatment Center, developing care plans, administering medications, and coordinating with the multidisciplinary team to support patients’ physical, emotional, and spiritual needs. The role is PRN, covering weekdays and every fourth weekend, with on‑site work in Pierre, SD.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Oncology Clinic

Avera Health

Pierre, SD, United States Full-time On-site USD28 - USD41 / hour

Registered Nurse (RN) at Avera St. Mary's Oncology Clinic in Pierre, SD. The Oncology team delivers compassionate, evidence‑based cancer care, coordinating multidisciplinary treatment plans and patient education. The RN administers medications, performs assessments, documents care, and supports physicians during procedures, ensuring seamless clinic flow.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Surgery Operating Room

Avera Health

Pierre, SD Full-time On-site USD32 - USD48 / hour

Registered Nurse in Avera St Mary's Surgery Operating Room delivers comprehensive patient care, reviews prescriptions, and coordinates with the healthcare team. Develops nursing care plans, sets objectives, and defines interventions.

Last seen Jul 12, 2026
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Registered Nurse (RN) - New Grad - August 2026

Avera Health

Pierre, SD Full-time On-site USD32 - USD48 / hour

Registered Nurse (RN) – New Grad – August 2026 at Avera St. Mary's Hospital in Pierre, SD. Provides patient care by reviewing physician prescriptions, communicating the nursing care plan, and coordinating with other healthcare providers. Develops nursing care plans, teaches patients and families, evaluates outcomes, maintains a safe environment, documents care, and keeps equipment and supplies ready.

Last seen Jul 13, 2026
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Registered Nurse (RN) | Same Day Surgery PACU

Avera Health

Pierre, SD Full-time On-site USD32 - USD48 / hour

Registered Nurse (RN) – Same Day Surgery PACU at Avera St. Mary's Hospital in Pierre, SD. This full‑time role provides comprehensive nursing care in the Post‑Anesthesia Care Unit (PACU) for patients undergoing same‑day surgeries. Responsibilities include reviewing physician orders, developing and implementing nursing care plans, administering medications, monitoring patient status, ensuring infection control, documenting care, maintaining equipment and supplies, and collaborating with the multidisciplinary team.

Last seen Jul 13, 2026
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Registered Nurse (RN) | Oncology Service Line

Avera Health

Pierre, SD, United States Full-time On-site USD28 - USD46 / hour

Avera Health seeks a Registered Nurse (RN) for its Oncology Service Line across five South Dakota locations. The RN will deliver comprehensive nursing care in infusion and clinic settings, coordinating with physicians and interdisciplinary teams to develop and implement individualized care plans.

Last seen Jul 13, 2026
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Registered Nurse (RN) | Primary Clinic Float

Avera Health

Pierre, SD Full-time On-site USD28 - USD41 / hour

Registered Nurse (RN) needed for primary clinic float in Pierre, SD. Provide comprehensive nursing care, administer medications, coordinate patient flow, and support providers during procedures. Work primarily days with occasional evenings or weekends.

Last seen Jul 13, 2026
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Registered Nurse (RN) | Women's Center

Avera Health

Pierre, SD Full-time On-site USD32 - USD48 / hour

Avera Health seeks a dedicated Registered Nurse for its Women’s Center in Pierre, SD. The RN will deliver comprehensive nursing care, develop individualized care plans, and collaborate with interdisciplinary teams to support patients, families, and staff. Responsibilities include medication administration, infection control, documentation, equipment upkeep, and patient education.

Last seen Jul 13, 2026
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Registered Nurse (RN) | Dialysis | PRN

Avera Health

Pierre, SD Part-time On-site USD32 - USD48 / hour

Registered Nurse (RN) – Dialysis – PRN at Avera St. Mary's Hospital in Pierre, SD. Provides care and treatment to patients on maintenance dialysis, including home dialysis training. Performs technical skills for dialysis treatments, oversees staff, ensures compliance with water room equipment, departmental policies, safety, infection control, CMS/ESRD-Renal Network, and quality assurance.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Same Day Surgery PACU

Avera Health

Pierre, SD Part-time On-site USD32 - USD48 / hour

Registered Nurse (RN) position in Same Day Surgery PACU at Avera St Mary's Hospital in Pierre, SD. Provides patient care, develops nursing care plans, coordinates with physicians, monitors patient status, ensures infection control, documents care, maintains equipment, supplies, and competences. Works day shift, Monday-Friday, 32hrs/2wks, occasional weekend/holiday/call.

Last seen Jul 12, 2026
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Registered Nurse (RN)

Edgewood Healthcare

Pierre, SD, United States Full-time On-site USD30 - USD32 / hour

Edgewood Healthcare seeks a dedicated Registered Nurse to deliver high‑quality care to residents in its Pierre assisted‑living community. The RN will lead clinical care, ensure regulatory compliance, and uphold HIPAA standards.

Last seen Jul 13, 2026
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Registered Nurse (RN) | Med Surg

Avera Health

Pierre, SD Full-time On-site USD32 - USD48 / hour

Registered Nurse (RN) | Med Surg at Avera St Mary's Hospital. Provides patient care, develops nursing care plans, teaches patients/families, evaluates outcomes, maintains safe environment, documents services, maintains equipment and supplies, and stays competent per leadership.

Last seen Jul 12, 2026
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Registered Nurse (RN) Traveler | AESS Temp Staffing

Avera Health

Pierre, SD Full-time On-site

Registered Nurse (RN) Traveler provides comprehensive nursing care across Avera facilities, developing care plans, teaching patients and families, evaluating outcomes, maintaining safe environments, documenting care, managing equipment and supplies, and upholding competence standards.

Last seen Jul 12, 2026
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Registered Nurse (RN) | Surgery Circulator | OR

Avera Health

Pierre, SD Part-time On-site USD32 - USD48 / hour

Registered Nurse (RN) provides patient care in the operating room, reviews prescriptions, develops care plans, teaches patients and families, evaluates outcomes, maintains infection control, documents care, operates equipment, manages supplies, and stays competent per leadership.

Last seen Jul 12, 2026
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Registered Nurse Jobs in South Dakota: FAQ

How many Registered Nurse jobs in South Dakota are open right now?

207 Registered Nurse jobs in South Dakota are live on NextGig, all seen active within the last 45 days. The list refreshes daily as new roles are posted and filled ones drop off.

What do Registered Nurse jobs in South Dakota pay?

19 of the 20 newest listings disclose pay, for example USD24 - USD41 / hour at Avera Health, USD32 - USD48 / hour at Avera Health, USD31 - USD46 / hour at Avera Health. Open a listing for the full compensation details.

Are any of these roles remote?

Of the 20 newest listings on this page, 1 is hybrid. The work model is shown on each job card.